Software and tools we develop

Rigid Density fitting:   
The density class in MODELLER. 

Mod-EM (density.grid_search in MODELLER): a method for rigid body cryoEM density fitting. 

Mod-EM dataset

Tutorial on combining comparative modelling and density fitting. 

Flexible fitting:
Flex-EM: A method for refinement of protein structures guided by cryoEM density.

Flex-EM tutorial

Cluster_fits: scripts for scoring and clustering fits in a density map.

Homology modelling and density fitting: 
CHOYCE: A web server for constrained homology modelling with cryoEM maps.
http://salilab.org/modeller/9v5/manual/node373.htmlhttp:////salilab.org/modeller/http://salilab.org/modeller/9v5/manual/node375.html#CMD:density.gridsearchhttp://salilab.org/mod-emhttp://salilab.org/mod-emhttp://salilab.org/modeller/ncmi_2008/http://salilab.org/Flex-EMhttp://topf-group.ismb.lon.ac.uk/flex-em/Flex-EM_tutorial.pdfhttp://topf-group.ismb.lon.ac.uk/flex-em/cluster_fits.htmlhttp://choyce.ismb.lon.ac.uk/Software_files/cluster_fits.htmlshapeimage_2_link_0shapeimage_2_link_1shapeimage_2_link_2shapeimage_2_link_3shapeimage_2_link_4shapeimage_2_link_5shapeimage_2_link_6shapeimage_2_link_7shapeimage_2_link_8shapeimage_2_link_9

Topf Lab